여성의 혈중 남성호르몬 수치와 성기능 장애의 상관관계 연구

Introduction and Aim. Sex hormones might induce significant changes in sexual desire, arousal, orgasm, and satisfaction. Decreased sexual desire and sexual dysfunctions in females have been associated with low levels of androgen. This study was to explore the relationship of sex hormones and sex hormone-binding globulin (SHBG) with female sexual dysfunction. Materials and Methods. Seventy-four women with sexual dysfunction were taken their medical history, personal history and physical examination. A self-reporting questionnaire on sexual problems and satisfaction was administered to them. Also levels of total, free, and bio-available testosterone, LH, FSH, estradiol, DHEAS and SHBG were measured, and free androgen index were calculated. Using Wilcoxon rank-sum test, the hormone levels of the sexual dysfunction groups were compared to those of control group. Nine patients were treated by testogel®. Results. The mean levels of LH, FSH, DHEA and DHEAS were lower in women with lack of sexual desire. The levels of DHEA was lower in the arousal disorder group (p<.05) and lower in the orgasmic disorder group (p<.01) than the control group. Sexual pain disorder groups showed lower estradiol level (p<.05). Among the nine patients receiving testosterone replacement therapy by using testogel®, 4 patients reported that symptoms were improved subjectively, the other 4 patients had not significant change, and the remaining 1 patient stopped the therapy due to side effect. Conclusion. The findings supported the concept that sex hormones significantly affect sexual response in women with sexual dysfunction. An androgenic hormone profile was associated with lack of libido, orgasmic disorder, and estrogen with pain disorder.